Revaccination and Duration of Protection
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چکیده
Pneumococcal polysaccharide vaccine induces an initial rise in ELISA antibody levels, which then decline over time and in older adults antibody levels measured 4 to 7 years post-vaccination tend to approximate pre-vaccination baseline levels (1-5). The clinical significance of this decline is not well defined, as immune correlates of protection for pneumococcal vaccine in adults have not been established and there are relatively limited clinical data regarding the duration of protection against invasive infection induced by pneumococcal polysaccharide vaccination.
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Making wider use of the world's most widely used vaccine: Bacille Calmette–Guérin revaccination reconsidered
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